Hereditary Spastic Paraplegia.

111 families, and Paskind and Stone (1933) also summarized the literature with accounts of another 36 reports from 40 families. Since then about 50 further reports have appeared, covering some 60 families, bringing the total so far to 176 reports of 215 families. Of these the majority have originated in Germany or elsewhere in Europe, but with a substantial number from the Americas. In Britain, however, reports are rare, the first being by Philip (1886). under the title of primary spastic paralysis. Then Gee (1889), Tooth (1891, two families), Ormerod (1904), Holmes (1905), Jones (1907), and Ogilvie (1908) each reported its occurrence, Gee, Ormerod, and Holmes describing associated amyotrophy. In the discussion following Ogilvie's report to the Royal Society of Medicine, Dr. Guthrie spoke of another family with the disease known to him. The next report was not until 1939 (Bell and Carmichael) and in recent years that of Bickerstaff (1950), describing the largest recorded British family. Garland and Astley (1950) and Dick and Stevenson (1953) have also described families. Manson (1920), Worster-Drought, Greenfield, and McMenemey (1940), and Sutherland (1957) each